IFN gamma Recombinant Monoclonal Antibody (209), Biotin (MA5-52310) (2024)

FAQs

What does interferon gamma do to the body? ›

IFN‐γ is primarily secreted by activated T cells and natural killer (NK) cells, and can promote macrophage activation, mediate antiviral and antibacterial immunity, enhance antigen presentation, orchestrate activation of the innate immune system, coordinate lymphocyte–endothelium interaction, regulate Th1/Th2 balance, ...

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines.

Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections.

IFN-γ has been shown to have profound effects on both innate and adaptive immunity that facilitate host protection. However, aberrant production of IFN-γ has been associated with disease pathology, including chronic autoimmune diseases such as inflammatory bowel disease and diabetes.

The most common side effects with ACTIMMUNE are "flu-like" symptoms such as fever, headache, chills, muscle pain, or fatigue, which may decrease in severity as treatment continues. Bedtime administration of ACTIMMUNE may help reduce some of these symptoms. Acetaminophen may be helpful in preventing fever and headache.

The result is reported in pg/mL. The assay range is approximately 0.4 to 298. The reference range for a healthy population is less than 8.6.

Interferon gamma, an important marker of response to immune checkpoint blockade in non-small cell lung cancer and melanoma patients.

When an inflammatory process (yang) is initiated, IFN-γ is produced to promote inflammation through multiple genes of the immune system (some are indicated). As IFN-γ reaches its peak level (the “hot” point), inflammation intensifies (enlargement of yang area) and compresses its opposite.

The interferon gamma release assay (IGRA) test is a blood test used to see whether a person has been exposed to the tuberculosis (TB) bacteria. The IGRA test is used to diagnose TB infection. This is when the TB bacteria is in the body but the person is not experiencing any symptoms suggestive of TB disease.

Interferon gamma has been shown to be a crucial player in the immune response against some intracellular pathogens, including that of Chagas disease. It has also been identified as having a role in seborrheic dermatitis. IFNG has a significant anti-viral effect in herpes simplex virus I (HSV) infection.

What releases IFN-gamma? ›

IFN-γ is produced by activated NK cells [1], CD4⁺ Th1 cells [2] and CD8⁺ cytotoxic T cells [3] and is a critical component of the cell-mediated immune response to intracellular pathogens and tumors (reviewed in [4]).

Interferon gamma-1b is used for the treatment of Chronic granulomatous disease and Osteopetrosis. Build, train, & validate predictive machine-learning models with structured datasets. IFN gamma stimulates expression of the immunoglobulin heavy chain C gamma 3 and C gamma 2a germline transcripts in B cells.

Interferon gamma-1b injection is used to reduce the frequency and severity of serious infections in people with chronic granulomatous disease (an inherited immune system disease). It is also used to slow down worsening of their condition in people with severe, malignant osteopetrosis (an inherited bone disease).

Interferon gamma (IFN-γ) belongs to the class II interferons, which are produced by T lymphocytes based on the IFNG gene (loc: 12q15). It activates macrophages/microglia and thus acts pro-inflammatory.

Interferons act via autocrine and paracrine pathways to induce an antiviral state in infected cells and in neighboring cells containing interferon receptors. Interferons are the frontline defenders against viral infection and their primary function is to locally restrict viral propagation.

Interferons are proteins that are part of your natural defenses. They tell your immune system that germs or cancer cells are in your body. And they trigger killer immune cells to fight those invaders. Interferons got their name because they "interfere" with viruses and keep them from multiplying.

Similar to all exposure to ionising radiation, high exposures can cause direct acute effects through immediate damage to cells. Low levels of exposure carry a stochastic health risk where the probability of cancer induction rises with increased exposure.

The development of interferon-gamma release assays (IGRAs) is used in the diagnosis of latent tuberculosis infection (LTBI). IGRAs are in vitro blood tests of cell-mediated immune response; they measure release of interferon (IFN)-gamma by T cells after stimulation by antigens unique to M. tuberculosis.